Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its Association With Mortality

EK Chowdhury; MR Nelson; LMH Wing; GLR Jennings; LJ Beilin; CM Reid; A Bruce; P Beckinsale; J Thompson; M McMurchie; G Fraser; D Gleave; V Cope; F DeLooze; S Moore; C Dibben; J Newbury; B McDermott; K Willson; C Bear; S Harrap; C Johnston; P Ryan; M Brown; P Ryan; P Fletcher; M Feneley; E Dewar; J Marley; J Marley; J Moss; P Webb; P Glasziou; F Boyle; J Primrose; L Piterman; F De Looze; J Dickinson; J Gambrill; P Joseph; G Donnan; T Morgan; J Whitworth; S MacMahon; C Silagy

Journal article

Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its Association With Mortality

EK Chowdhury, MR Nelson, LMH Wing, GLR Jennings, LJ Beilin, CM Reid, A Bruce, P Beckinsale, J Thompson, M McMurchie, G Fraser, D Gleave, V Cope, F DeLooze, S Moore, C Dibben, J Newbury, B McDermott, K Willson, C Bear Show all

Journal of the American Heart Association | WILEY | Published : 2019

DOI: 10.1161/JAHA.119.012630

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Abstract

Background: Information is scarce regarding effects of antihypertensive medication on blood pressure variability (BPV) and associated clinical outcomes. We examined whether antihypertensive treatment changes BPV over time and whether such change (decline or increase) has any association with long-term mortality in an elderly hypertensive population. Methods and Results: We used data from a subset of participants in the Second Australian National Blood Pressure study (n=496) aged ≥65 years who had 24-hour ambulatory blood pressure recordings at study entry (baseline) and then after a median of 2 years while on treatment (follow-up). Weighted day-night systolic BPV was calculated for both base..

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University of Melbourne Researchers

Stephen Harrap Author

Colin Johnston Author

Geoffrey Donnan Author

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Awarded by Merck Sharp and Dohme

Funding Acknowledgements

ANBP2 (Second Australian National Blood Pressure Study) was supported by the Australian Commonwealth Department of Health and Aging, the National Health and Medical Research Council (NHMRC) of Australia (grant no. 546272), and Merck Sharp & Dohme Pty. Ltd. The long-term ANBP2 cohort follow-up study was supported by an NHMRC program grant (no. 546272) awarded to Christopher M. Reid, who is supported by an NHMRC research fellowship (no. 1045862).